YKL-05-099 | SIK inhibitor | Probechem Biochemicals

Chemical Structure : YKL-05-099

CAS No.: 1936529-65-5

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YKL-05-099 (YKL 05-099)

货号: PC-42327Not For Human Use, Lab Use Only.

YKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, 2 and 3, respectively.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

YKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, 2 and 3, respectively
YKL-05-099 displays increased SIK selectivity and enhanced pharmacokinetic properties compared with HG-9-91-01.
YKL-05-099 reduces LPS stimulated phosphorylation of HDAC5 at the SIK-specific phosphorylation site Ser259, increases expression of the CREB target genes Il10 and Nurr77, suppresses production of TNFα, IL-6 and IL-12p40 in BMDMs.
YKL-05-099 is a useful probe to investigate SIK function in vivo.

物理化学性质&存储条件

分子量	600.11046
分子式	C32H34ClN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 103.33 mg/mL; PBS: 100 mM
Chemical Name/SMILES	Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-

参考文献

1. Sundberg TB, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.

2. Wein MN, et al. Nat Commun. 2016 Oct 19;7:13176.

YKL-05-099 (YKL 05-099)

生物&药学活性

物理化学性质&存储条件

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YKL-05-099 (YKL 05-099)

生物&药学活性

物理化学性质&存储条件

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