YK-4-279 | EWS-FLI1 inhibitor | Probechem Biochemicals

Chemical Structure : YK-4-279

CAS No.: 1037184-44-3

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YK-4-279 (EWS-FLI1 inhibitor)

货号: PC-22540Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

YK-4-279 is a specific small molecule inhibitor of EWS-FLI1 interaction with RNA helicase A with SPR KD of 9.48 uM for EWS-FLI1, reduces EWS-FLI1 functional activity, also reduces EWS-FLI1 modulated transcription.
YK-4-279 specifically inhibits Ewing's Sarcoma Family Tumors (ESFT) cell growth (IC50 values between 0.5 to 2 μM) and induces apoptosis, but not cell death in the non-transformed cells.
YK-4-279 (60-75 mg/kg) inhibits ESFT xenograft growth in CHP-100 xenograft tumors.

物理化学性质&存储条件

分子量	366.19
分子式	C17H13Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,7-Dichloro-3-hydroxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)indolin-2-one

参考文献

1. Erkizan HV, et al. Nat Med. 2009 Jul;15(7):750-6.

2. Erkizan HV, et al. Clin Cancer Res. 2010 Aug 15;16(16):4077-83.

YK-4-279 (EWS-FLI1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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YK-4-279 (EWS-FLI1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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