YK-3-237 |CAS:1215281-19-8 Probechem Biochemicals

Chemical Structure : YK-3-237

CAS No.: 1215281-19-8

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YK-3-237 (YK-3 237)

货号: PC-60825Not For Human Use, Lab Use Only.

YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
YK-3-237 demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase.
YK-3-237 enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).

物理化学性质&存储条件

分子量	372.18
分子式	C19H21BO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid

参考文献

1. Yi YW, et al. Oncotarget. 2013 Jul;4(7):984-94.

2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.

3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):971-7.

YK-3-237 (YK-3 237)

生物&药学活性

物理化学性质&存储条件

参考文献

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YK-3-237 (YK-3 237)

生物&药学活性

物理化学性质&存储条件

参考文献

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