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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-YK-2168 hydrochloride
YK-2168 hydrochloride

Chemical Structure : YK-2168 hydrochloride

CAS No.: 2571068-75-0

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YK-2168 hydrochloride (YK2168 hydrochloride)

货号: PC-23020Not For Human Use, Lab Use Only.

YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.
YK-2168 exhibits cell viability potency (IC50=53.4 nM) against MV4-11 cells, inhibits the CDK9 signaling and induced apoptosis.
YK-2168 demonstrated dose dependent anti-tumor effects, resulted in many mouse partial responses (PR) in a mouse gastric cancer SNU16 CDX model.

物理化学性质&存储条件

分子量 352.26
分子式 C16H19Cl2N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrrolo[2,3-b]pyridine, 5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-2-(4-piperidinyl)-, hydrochloride (1:1)

参考文献

1. Liu Y, et al. Bioorg Med Chem Lett. 2024 Aug 31:129941.

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