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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-YIR-821
YIR-821

Chemical Structure : YIR-821

CAS No.: 1883372-91-5

YIR-821 (YIR821)

货号: PC-62901Not For Human Use, Lab Use Only.

YIR-821 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.8 uM against YTA48P virus with no significant cytotoxicity (CC50>200 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YIR-821 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.8 uM against YTA48P virus with no significant cytotoxicity (CC50>200 uM).
    YIR-821 is a useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.

    物理化学性质&存储条件

    分子量 534.102
    分子式 C26H40ClN7O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N1-(4-chlorophenyl)-N2-(1-(2-(5-guanidinopentanamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide

    参考文献

    1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.

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