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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-YIR-819
YIR-819

Chemical Structure : YIR-819

CAS No.: 1883372-86-8

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YIR-819 (YIR 819)

货号: PC-49592Not For Human Use, Lab Use Only.

YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
    YIR-819 is a useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.

    物理化学性质&存储条件

    分子量 492.02
    分子式 C23H34ClN7O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(4-chlorophenyl)-N2-(1-(2-(2-guanidinoacetamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide

    参考文献

    1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.

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