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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-BCRP-YHO-13351
YHO-13351

Chemical Structure : YHO-13351

CAS No.: 1346753-00-1

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YHO-13351 (YHO13351)

货号: PC-43182Not For Human Use, Lab Use Only.

YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.
YHO-13351 is rapidly converted into YHO-13177 after its oral or intravenous administration.
YHO-13351 significantly increases the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model coadministration of irinotecan.

物理化学性质&存储条件

分子量 579.7286
分子式 C27H37N3O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 38 mg/mL
Chemical Name/SMILES

Glycine, N,N-diethyl-, 1-[5-[(1Z)-2-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-2-thienyl]-4-piperidinyl ester, methanesulfonate (1:1)

参考文献

1. Yamazaki R, et al. Mol Cancer Ther. 2011 Jul;10(7):1252-63.

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