YHJ1039 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : YHJ1039

CAS No.: 1644557-92-5

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YHJ1039 (YHJ 1039)

货号: PC-21047Not For Human Use, Lab Use Only.

YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM).

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM).
YHJ1039 remarkably suppresses the proliferation of human cancer cell lines, including HCT-116, MDA-MD-231, and MV4-11.
YHJ1039 not only induces apoptosis but also effectively prevents cancer cell invasion by FAK inhibition.
YHJ1039 inhibits tumor growth and metastasis in MDA-MB-231 xenograft and an orthotopic mouse model.
YHJ1039 potently reduces phosphorylation of FLT3, STAT5, and ERK in Ba/F3 harboring the FLT3 mutant (ITD, D835Y, and ITD/D835Y, respectively) and tumor growth in an MV4–11 inoculated xenograft mouse model.

物理化学性质&存储条件

分子量	508.66
分子式	C25H28N6O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

参考文献

1. Hanna Cho, et al. J Med Chem. 2021 Aug 26;64(16):11934-11957.

YHJ1039 (YHJ 1039)

生物&药学活性

物理化学性质&存储条件

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YHJ1039 (YHJ 1039)

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物理化学性质&存储条件

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