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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-YHD-26
YHD-26

Chemical Structure : YHD-26

CAS No.:

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YHD-26 (YHD26)

货号: PC-28011Not For Human Use, Lab Use Only.

YHD-26 is a novel ferroptosis inducer and dul GPX4/PARP inhibitor, inhibits PARP (IC50=92 nM) and binds GPX4 (KD=23.4 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YHD-26 is a novel ferroptosis inducer and dual GPX4/PARP inhibitor, inhibits PARP (IC50=92 nM) and binds GPX4 (KD=23.4 uM).
YHD-26 exerts potent antiproliferative effects, induces ferroptosis, and impairs DNA damage repair, resulting in G2/M arrest in MDA-MB-468 and 4T1 cells.
YHD-26 inhibited GPX4 and PARP, validating its in vivo antitumor efficacy and dual-target engagement in 4T xenograft mouse model。

物理化学性质&存储条件

分子量 455.54
分子式 C25H21N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(4-(1-(4-ethynylthiazole-2-carbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

参考文献

1. Bao H, et al. Biochem Pharmacol. 2026 Sep 4:118433.

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