YH12852 | 5-HT4 agonist | Probechem Biochemicals

Chemical Structure : YH12852

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YH12852 (YH 12852)

货号: PC-62093Not For Human Use, Lab Use Only.

YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.

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生物&药学活性

YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.
YH12852 exhibits high selectivity for the 5-HT4 receptor over other 5-HT receptor subtypes and non-5-HT receptors.
YH12852 significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus.

物理化学性质&存储条件

分子量	399.46
分子式	C19H25N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide

参考文献

1. Hussain Z, et al. Neurogastroenterol Motil. 2017 Oct;29(10):1-6.

2. Jeong EJ, et al. Br J Pharmacol. 2018 Feb;175(3):485-500.

YH12852 (YH 12852)

生物&药学活性

物理化学性质&存储条件

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YH12852 (YH 12852)

生物&药学活性

物理化学性质&存储条件

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