YH-685 | Mtb Cyt-bd inhibitor | Probechem Biochemicals

Chemical Structure : YH-685

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YH-685 (YH685)

货号: PC-28616Not For Human Use, Lab Use Only.

YH-685 is a specific small molecule inhibitor of Mycobacterium tuberculosis (Mtb) cytochrome bd terminal oxidase (Cyt-bd), inhibits Cyt-bcc-deficient M. smegmatis with MIC of 0.8 uM, enhances TB47-mediated inhibition of planktonic and intracellular Mtb.

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生物&药学活性

YH-685 is a specific small molecule inhibitor of Mycobacterium tuberculosis (Mtb) cytochrome bd terminal oxidase (Cyt-bd), inhibits Cyt-bcc-deficient M. smegmatis with MIC of 0.8 uM, enhances TB47-mediated inhibition of planktonic and intracellular Mtb.
YH-685 inhibits oxygen consumption rate (OCR) mycobacterial respiratory chain with IC50 of 0.45 uM in inverted membrane vesicles (IMVs) prepared from the Δbcc strain overexpressing Mtb Cyt-bd.
YH-685 enhances the growth-inhibitory effect of TB47 in both planktonic cultures and infected human macrophages.

物理化学性质&存储条件

分子量	385.29
分子式	C18H12F5NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-difluoro-1-hydroxy-2-methyl-3-(4-(trifluoromethoxy)benzyl)quinolin-4(1H)-one

参考文献

1. Qiao Qin, et al. ACS Med Chem Lett. 2026 Sep 18;17(10):2182-2190.

YH-685 (YH685)

生物&药学活性

物理化学性质&存储条件

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YH-685 (YH685)

生物&药学活性

物理化学性质&存储条件

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