YC8-02 | SIRT3 inhibitor | Probechem Biochemicals

Chemical Structure : YC8-02

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YC8-02 (SIRT3 inhibitor YC8-02)

货号: PC-72771Not For Human Use, Lab Use Only.

YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.

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生物&药学活性

YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.
YC8-02 inhibits SIRT1 and SIRT2 with IC50 of 2.8 and 0.062 uM in in vitro biochemical assays.
YC8-02 manifested increased ratio of mitochondria to total cell concentration, as measured by mass spectrometry in purified mitochondria extracts and total cell lysates.
YC8-02 increased mitochondrial protein acetylation, inhibited GDH activity and induced autophagy in DLBCL cells.
YC8-02 could phenocopy the effects of SIRT3 depletion.
YC8-02 (30 mg/kg) caused regression of the tumors in DLBCL xenografts, with no evidence of discomfort or weight loss.

物理化学性质&存储条件

分子量	754.071
分子式	C46H64N3O2PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility
Chemical Name/SMILES	(S)-N-(3-hydroxyphenyl)-6-tetradecanethioamido-2-((2-(triphenyl-l5-phosphanyl)ethyl)amino)hexanamide

参考文献

1. Meng Li, et al. Cancer Cell. 2019 Jun 10;35(6):916-931.e9.

YC8-02 (SIRT3 inhibitor YC8-02)

生物&药学活性

物理化学性质&存储条件

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YC8-02 (SIRT3 inhibitor YC8-02)

生物&药学活性

物理化学性质&存储条件

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