YC-001 | Rod opsin antagonist | Probechem Biochemicals

Chemical Structure : YC-001

CAS No.: 748778-73-6

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YC-001 (YC001)

货号: PC-35071Not For Human Use, Lab Use Only.

YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin.

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生物&药学活性

YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin.
YC-001 demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity.
YC-001 binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant.
YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration.

物理化学性质&存储条件

分子量	282.756
分子式	C12H7ClO2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-chlorothiophen-2-yl)-3-(thiophen-2-yl)furan-2(5H)-one

参考文献

1. Chen Y, et al. Nat Commun. 2018 May 17;9(1):1976.

YC-001 (YC001)

生物&药学活性

物理化学性质&存储条件

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YC-001 (YC001)

生物&药学活性

物理化学性质&存储条件

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