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首页-小分子抑制剂&激动剂-Others-Other Targets-YB-B1
YB-B1

Chemical Structure : YB-B1

CAS No.: 1184980-85-5

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YB-B1 (YB-1/YBX1 inhibitor)

货号: PC-25207Not For Human Use, Lab Use Only.

YB-B1 is a small molecule Y-box-binding protein 1 (YBX1, YB-1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YB-B1 is a small molecule Y-box-binding protein 1 (YBX1, YB-1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.
    YB-B1 significantly suppresses proliferation of HEY and OV90 cells with IC50 of 3.5 and 11.9 uM respectively.
    YB-B1 decreases the expression of CCNL2 and YBX1.
    YB-B1 exhibits a synergistic effect with cisplatin, enhances chemotherapy-induced cytotoxicity in ovarian cancer cells and the PDX model.

    物理化学性质&存储条件

    分子量 388.43
    分子式 C21H20N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N5-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-2-ylmethyl)-1H-imidazole-4,5-dicarboxamide

    参考文献

    1. Zhang K, et al. J Ovarian Res. 2025 Jul 24;18(1):162.

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