YB-537 | Quinone reductase 2 inhibitor | Probechem Biochemicals

Chemical Structure : YB-537

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YB-537 (YB537, YB 537)

货号: PC-21015Not For Human Use, Lab Use Only.

YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
YB-537 binds to the catalytic site through a series of hydrophobic and hydrogen bonds with both FAD and amino acids from both QR2 monomers.
YB-537 can bind native QR2 in human cells and replicate the effects seen using genetic QR2 removal.
YB-537 enhances cortical and hippocampal learning in mice and rats.
YB-537 (50 mg/kg, in drinking water) improves cognitive function in 9- month-old 5xFAD female mice.
YB-537 reduces metabolic burden and reverses Alzheimer's disease phenotype in mice.

物理化学性质&存储条件

分子量	370.47
分子式	C19H22N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=S(C1=CC(C2=CN3C=CC=C(C)C3=N2)=CC=C1C)(N4CCNCC4)=O

参考文献

1. Nathaniel L Gould, et al. J Clin Invest. 2023 Aug 10;e162120.

YB-537 (YB537, YB 537)

生物&药学活性

物理化学性质&存储条件

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YB-537 (YB537, YB 537)

生物&药学活性

物理化学性质&存储条件

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