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首页-小分子抑制剂&激动剂-Others-Other Targets-YB-0158
YB-0158

Chemical Structure : YB-0158

CAS No.: 1144043-83-3

YB-0158 (YB0158)

货号: PC-72907Not For Human Use, Lab Use Only.

YB-0158 (YB0158) is a β-turn peptidomimetic small molecule altering key hallmarks of human colorectal tumorigenesis, with high predicted affinity for Sam68.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YB-0158 (YB0158) is a β-turn peptidomimetic small molecule altering key hallmarks of human colorectal tumorigenesis, with high predicted affinity for Sam68.
YB-0158 elicits a cancer-selective response impeding main cancer stem cell hallmarks .
YB-0158 blocks icolorectal cancer stem cell activity in tumor organoids and in vivo systems.
Sam68 is a putative target of β-turn peptidomimetic molecules in cancer cells.

物理化学性质&存储条件

分子量 705.61
分子式 C32H34N7O7P.2Na
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, hexahydro-8-(1H-indazol-7-ylmethyl)-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-2-(2-propen-1-yl)-, sodium salt (1:2), (6S,9aS)-

参考文献

1. Angelique N Masibag, et al. iScience. 2021 Nov 14;24(12):103442.

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