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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-YAP1 inhibitor CA3
YAP1 inhibitor CA3

Chemical Structure : YAP1 inhibitor CA3

CAS No.: 300802-28-2

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YAP1 inhibitor CA3 (CIL56)

货号: PC-60375Not For Human Use, Lab Use Only.

YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2380 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity
YAP1 inhibitor CA3 (CIL56) also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo.
YAP1 inhibitor CA3 (CIL56) can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU.
YAP1 inhibitor CA3 (CIL56)  triggers nonapoptotic cell death, a potent and selective probe of ferroptosis.
YAP1 inhibitor CA3 (CIL56)  stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.

物理化学性质&存储条件

分子量 489.6
分子式 C23H27N3O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,7-bis(piperidin-1-ylsulfonyl)-9H-fluoren-9-one oxime

参考文献

1. Dixon SJ, et al. ACS Chem Biol. 2015 Jul 17;10(7):1604-9.

2. Song S, et al. Mol Cancer Ther. 2018 Feb;17(2):443-454. 

3. Shimada K, et al. Nat Chem Biol. 2016 Jul;12(7):497-503.

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