YAP-TEAD inhibitor BY03

Chemical Structure : YAP-TEAD inhibitor BY03

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货号: PC-23113Not For Human Use, Lab Use Only.

BY03 is a small molecule inhibitor of YAP-TEAD interaction with IC50 of 1.5 uM in TEAD-dependent luciferase assay in overexpressing the TEAD luciferase plasmid in HEK293T.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

BY03 is a small molecule inhibitor of YAP-TEAD interaction with IC50 of 1.5 uM in TEAD-dependent luciferase assay in overexpressing the TEAD luciferase plasmid in HEK293T.
BY03 directly bind to TEAD1 with SPR KD value of 9.4 μM.
BY03 (1-15 uM) inhibits YAP-TEAD target genes (CYR61, AMOT) in HEK293T cells.

物理化学性质&存储条件

分子量	484.61
分子式	C29H28N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dibenzyl-2-(N-(o-tolyl)phenylsulfonamido)acetamide

参考文献

1. Kim J, et al. Cancers (Basel). 2021 Aug 23;13(16):4246.