Y15 |CAS:4506-66-5 Probechem Biochemicals

Chemical Structure : Y15

CAS No.: 4506-66-5

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Y15 (FAK inhibitor Y15;Y-15;FAK Inhibitor 14)

货号: PC-43036Not For Human Use, Lab Use Only.

FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.

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50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥1980	In stock
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生物&药学活性

FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.
Y15 does not significantly decrease kinase activity of the other kinases (Pyk2 autophosphorylation).
Y15 directly and specifically decreases Y397-phosphorylation of FAK in vitro, inhibits cancer cell viability in vitro, causes detachment, decreases cell adhesion and blocks tumor growth in vivo.

物理化学性质&存储条件

分子量	284.0142
分子式	C6H14Cl4N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 59 mg/mL
Chemical Name/SMILES	1,2,4,5-Benzenetetramine, hydrochloride (1:4)

参考文献

1. Hochwald SN, et al. Cell Cycle. 2009 Aug;8(15):2435-43.

2. Zheng D, et al. Mol Carcinog. 2010 Feb;49(2):200-9.

3. Beierle EA, et al. Cell Cycle. 2010 Mar 1;9(5):1005-15.

4. Golubovskaya VM, et al. J Med Chem. 2008 Dec 11;51(23):7405-16.

Y15 (FAK inhibitor Y15;Y-15;FAK Inhibitor 14)

生物&药学活性

物理化学性质&存储条件

参考文献

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Y15 (FAK inhibitor Y15;Y-15;FAK Inhibitor 14)

生物&药学活性

物理化学性质&存储条件

参考文献

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