Y08060 | BET inhibitor | Probechem Biochemicals

Chemical Structure : Y08060

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Y08060 (Y 08060)

货号: PC-63245Not For Human Use, Lab Use Only.

Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300.

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100 mg		Get quote

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生物&药学活性

Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300.
Y08060 suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines, such as C4-2B, LNCaP, and 22Rv1.
Y08060 demonstrates good PK profile with high oral bioavailability (61.54%).

物理化学性质&存储条件

分子量	471.322
分子式	C18H19BrN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide

参考文献

1. Xiang Q, et al. ACS Med Chem Lett. 2018 Feb 13;9(3):262-267.

Y08060 (Y 08060)

生物&药学活性

物理化学性质&存储条件

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Y08060 (Y 08060)

生物&药学活性

物理化学性质&存储条件

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