Y-39983 |CAS:471843-75-1 Probechem Biochemicals

Chemical Structure : Y-39983

CAS No.: 471843-75-1

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Y-39983 (Y-33075 hydrochloride;Y39983)

货号: PC-42222Not For Human Use, Lab Use Only.

Y-39983 (Y-33075 hydrochloride) is a potent and selective p160 ROCK inhibitor with Ki of 140 nM.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

Y-39983 (Y-33075 hydrochloride) is a potent and selective p160 ROCK inhibitor with Ki of 140 nM.
Y-39983 displays > 200-fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase。
Y-39983 promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats, shows therapeutic potential for axonal regeneration of RGCs in the treatment of diseases with degenerating axons of RGCs including glaucoma.

物理化学性质&存储条件

分子量	316.79
分子式	C16H17ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl- hydrochloride

参考文献

1. Sagawa H, et al. Exp Neurol. 2007 May;205(1):230-40.

2. Tokushige H, et al. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3216-22.

3. Okumura N, et al. Invest Ophthalmol Vis Sci. 2014 Jan 15;55(1):318-29.

Y-39983 (Y-33075 hydrochloride;Y39983)

生物&药学活性

物理化学性质&存储条件

参考文献

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Y-39983 (Y-33075 hydrochloride;Y39983)

生物&药学活性

物理化学性质&存储条件

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