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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-Y-27632
Y-27632

Chemical Structure : Y-27632

CAS No.: 146986-50-7

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Y-27632 (Y 27632;Y27632)

货号: PC-42232Not For Human Use, Lab Use Only.

Y-27632 (Y27632) is a potent, selective ROCK1 (p160 ROCK) inhibitor with Ki of 140 nM in cell-free assay.

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25 mg ￥1480 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Y-27632 (Y27632) is a potent, selective ROCK1 (p160 ROCK) inhibitor with Ki of 140 nM in cell-free assay.
Y-27632 exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
Y-27632 consistently suppresses Rho-induced, p160ROCK-mediated formation of stress fibres in cultured cells and dramatically corrects hypertension in several hypertensive rat models.

物理化学性质&存储条件

分子量 247.336
分子式 C14H21N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-

参考文献

1. Uehata M, et al. Nature. 1997 Oct 30;389(6654):990-4.

2. Hirose M, et al. J Cell Biol. 1998 Jun 29;141(7):1625-36.

3. Ishizaki T, et al. Mol Pharmacol. 2000 May;57(5):976-83.

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