XZH-5 |CAS:1360562-98-6 Probechem Biochemicals

Chemical Structure : XZH-5

加入收藏

XZH-5 (XZH5)

货号: PC-61667Not For Human Use, Lab Use Only.

XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes.
XZH-5 inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin,.
XZH-5 demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration.
XZH-5 blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.

物理化学性质&存储条件

分子量	537.463
分子式	C22H25F6N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl Na-(((3,5-bis(trifluoromethyl)phenyl)carbamoyl)-L-valyl)-Nt-methyl-L-histidinate

参考文献

1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10.

2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7.

3. Liu A, PLoS One. 2012;7(10):e46624.

4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55.

XZH-5 (XZH5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

XZH-5 (XZH5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.