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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-XY153
XY153

Chemical Structure : XY153

CAS No.: 2933176-32-8

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XY153 (XY 153)

货号: PC-73224Not For Human Use, Lab Use Only.

XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.
    XY153 displays 6-fold BRD4 BD2 domain selectivity over other BET BD2 domains.
    XY153 displayed potent antiproliferative activity against multiple tumor cell lines, especially MV4-11 (IC50=0.55 nM), also demonstrated good metabolic stability in vitro.

    物理化学性质&存储条件

    分子量 555.650
    分子式 C33H34FN3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-cyclopentyl-1H-imidazol-5-yl)-7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one

    参考文献

    1. Junhua Li, et al. J Med Chem. 2022 Mar 25. doi: 10.1021/acs.jmedchem.2c00100.

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