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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-XY-4083
XY-4083

Chemical Structure : XY-4083

CAS No.: 917837-54-8

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XY-4083 (AVL-3288, CCMI)

货号: PC-21453Not For Human Use, Lab Use Only.

XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively.

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10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively.
XY-4083 does not evoke modulation of EC5-evoked currents at human α4β2, rat α3β4, and mouse α1β1γδ nAChR subtypes or human 5-HT3A receptors expressed in oocytes.
XY-4083 also evokes positive modulation of choline-evoked currents in SH-SY5Y cells transfected with α7 nAChRs.
XY-4083 corrects sensory-gating deficits and improves working memory, effects consistent with cognitive enhancement in rodent models.

物理化学性质&存储条件

分子量 388.25
分子式 C19H15Cl2N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide

参考文献

1. Ng HJ, et al. Proc Natl Acad Sci U S A. 2007.

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