XY-280 | IL-1R4/ST2 inhibitor | Probechem Biochemicals

Chemical Structure : XY-280

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XY-280 (trans-XY-280, XY280)

货号: PC-27761Not For Human Use, Lab Use Only.

XY-280 is a potent, selective, brain penetrant inhibitor of Interleukin-1 receptor-4 (IL-1R4, ST2) with IC50 of 5.85 uM.

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100 mg		Get quote

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生物&药学活性

XY-280 is a potent, selective, brain penetrant inhibitor of Interleukin-1 receptor-4 (IL-1R4, ST2) with IC50 of 5.85 uM.
XY-280 significantly suppressed the release of PGE2, IL-1β, and IL-6 in LPS-stimulated primary microglia cells.
XY-280 inhibited the ST2/IL-33 signaling in primary microglia cells and suppressed the downstream NF-κB activation.
XY-280 (20 mg/kg, i.p.) markedly reduced mRNA levels of key inflammatory cytokines and chemokines in LPS-induced neuroinflammation model.

物理化学性质&存储条件

分子量	404.51
分子式	C24H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-4-((2S,5R)-5-methyl-1-((5-(4-nitrophenyl)-1H-pyrrol-2-yl)methyl)pyrrolidin-2-yl)aniline

参考文献

1. Yuan X, et al. ACS Med Chem Lett. 2026 Jul 27;17(8):1915-1922.

XY-280 (trans-XY-280, XY280)

生物&药学活性

物理化学性质&存储条件

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XY-280 (trans-XY-280, XY280)

生物&药学活性

物理化学性质&存储条件

参考文献

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