XX-650-23 | CREB inhibitor | Probechem Biochemicals

Chemical Structure : XX-650-23

CAS No.: 117739-40-9

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XX-650-23 (XX 650 23)

货号: PC-61254Not For Human Use, Lab Use Only.

XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
XX-650-23 suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest.
XX-650-23 significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.

物理化学性质&存储条件

分子量	288.306
分子式	C18H12N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-cyanophenyl)-3-hydroxy-2-naphthamide

参考文献

1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311.

2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97.

XX-650-23 (XX 650 23)

生物&药学活性

物理化学性质&存储条件

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XX-650-23 (XX 650 23)

生物&药学活性

物理化学性质&存储条件

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