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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-XSY12
XSY12

Chemical Structure : XSY12

CAS No.: 3143206-43-0

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XSY12 (XSY-12)

货号: PC-28639Not For Human Use, Lab Use Only.

XSY12 is a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletion (DC50=2.21 μM, Dmax=80.2%), promotes proteasome-dependent NSD3 depletion, reduces H3K36 methylation, and induces apoptosis and G2/M arrest in NSD3-dependent models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XSY12 is a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletion (DC50=2.21 μM, Dmax=80.2%), promotes proteasome-dependent NSD3 depletion, reduces H3K36 methylation, and induces apoptosis and G2/M arrest in NSD3-dependent models.

物理化学性质&存储条件

分子量 546.00
分子式 C32H21ClFN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-chlorophenyl)-N-(9H-fluoren-9-yl)-3-((5-fluoropyridin-3-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide

参考文献

1. Si-Yu Xiu, et al. J Med Chem. 2026 Aug 13;69(15):18637-18664.

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