XST-20 | FOXM1 inhibitor | Probechem Biochemicals

Chemical Structure : XST-20

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XST-20 (XST20)

货号: PC-38900Not For Human Use, Lab Use Only.

XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.

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生物&药学活性

XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.
XST-20 (40 μM, 48h) exhibited a significant inhibitor effect on both A2780 and SKOV3 cells, downregulated FOXM1 downstream targets CCNB1 and CDC25B expression.
XST-20 (25 and 50 μM) significantly reduced the protein level of CCNB1 and PLK1 while FOXM1 protein level was not changed in ovarian cancer cell lines.
XST-20 significantly reduced the colony-forming efficiency and induced cell cycle arrest and apoptosis.

物理化学性质&存储条件

分子量	355.478
分子式	C22H29NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(4-(benzyloxy)phenoxy)ethoxy)ethyl)cyclopentanamine

参考文献

1. Zaixin Zhang, et al. Cell Death Discov. 2022 Jun 9;8(1):280.

XST-20 (XST20)

生物&药学活性

物理化学性质&存储条件

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XST-20 (XST20)

生物&药学活性

物理化学性质&存储条件

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