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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-XS-060
XS-060

Chemical Structure : XS-060

CAS No.: 346721-50-4

XS-060 (XS060)

货号: PC-20839Not For Human Use, Lab Use Only.

XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.

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5 mg ¥880 In stock
10 mg ¥1280 In stock
25 mg ¥2180 In stock
50 mg ¥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
XS-060 binds to RXRα with Kd=1.3 μM and effectively induces mitotic arrest and chromosome aberrations in an RXRα-dependent and cancer-specific manner.
XS-060 displays a promising anticancer activity in vitro and in vivo.

物理化学性质&存储条件

分子量 334.38
分子式 C20H18N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Methoxybenzeneacetic acid 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide

参考文献

1. Wang Q, et al. Bioorg Chem. 2022 Nov;128:106069.

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