XRK3F2 |CAS: 2375193-43-2 Probechem Biochemicals

Chemical Structure : XRK3F2

CAS No.: 2375193-43-2

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XRK3F2 (p62 inhibitor XRK3F2)

货号: PC-61297Not For Human Use, Lab Use Only.

XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.

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10 mg	￥1280	In stock
25 mg	￥1880	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
XRK3F2 inhibits TNFα-induced osteoclast formation, and has IC50 of 4.35 uM 5TGM1 cells and 4.6 uM for the human MM1.S cell line.
XRK3F2 induces new cortical bone formation in MMBD in vivo, and alters MM cell-BMSC cell interactions by reducing MM cell-derived TNFα in the myeloma microenvironment.

物理化学性质&存储条件

分子量	435.896
分子式	C23H24ClF2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride

参考文献

1. Teramachi J, et al. Leukemia. 2016 Feb;30(2):390-8.

2. Adamik J, et al. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.

XRK3F2 (p62 inhibitor XRK3F2)

生物&药学活性

物理化学性质&存储条件

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XRK3F2 (p62 inhibitor XRK3F2)

生物&药学活性

物理化学性质&存储条件

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