XOB | 5-HT2A/VGSC antagonist | Probechem Biochemicals

Chemical Structure : XOB

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XOB (5-HT2A/VGSC antagonist)

货号: PC-22491Not For Human Use, Lab Use Only.

XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).
XOB antagonizes 5-HT-stimulated, Gq-mediated, calcium flux at 5-HT2A receptors at low micromolar concentrations while displaying negligible affinity and activity at 5-HT1A, 5-HT2B, and 5-HT2C receptors.
XOB simultaneously antagonizes two key therapeutic targets of bipolar disorder, 5-HT2A receptors and voltage-gated sodium channels (VGSCs), in heterologous cells, and inhibits the intrinsic excitability of mouse prefrontal cortex layer V pyramidal neurons in brain slices.

物理化学性质&存储条件

分子量	492.50
分子式	C26H38BrNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2,5-dimethoxyphenethyl)-6-(4-phenylbutoxy)hexan-1-amine

参考文献

1. Nicholas Denomme, et al. Mol Pharmacol. 2024 May 31:MOLPHARM-AR-2023-000837.