XMU-MP-2 |CAS:2031152-10-8 Probechem Biochemicals

Chemical Structure : XMU-MP-2

CAS No.: 2031152-10-8

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XMU-MP-2

货号: PC-61652Not For Human Use, Lab Use Only.

XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg	￥8980	In stock
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100 mg		Get quote

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生物&药学活性

XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM.
XMU-MP-2 inhibits the autophosphorylation of BRK Y342 in dose-dependent manner (maximum inhibition at 500 nM), abolishes phosphorylation levels of STAT3 Y705 and STAT5 Y694.
XMU-MP-2 blocks proliferation and survival of BRK-transformed Ba/F3 cells with IC50 of 29.7 nM.
XMU-MP-2 cooperates strongly with HER2 inhibitor or ER blockade to block breast cancer cell proliferation in vitro and in vivo.

物理化学性质&存储条件

分子量	618.665
分子式	C32H33F3N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(7-((6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)amino)-1-methyl-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

参考文献

1. Jiang J, et al. Cancer Res. 2017 Jan 1;77(1):175-186.

XMU-MP-2

生物&药学活性

物理化学性质&存储条件

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XMU-MP-2

生物&药学活性

物理化学性质&存储条件

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