XMU-MP-1 | MST1/2 inhibitor | Probechem Biochemicals

Chemical Structure : XMU-MP-1

CAS No.: 2061980-01-4

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XMU-MP-1 (MST1/2 inhibitor)

货号: PC-42188Not For Human Use, Lab Use Only.

XMU-MP-1 is a potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20-like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively.

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2 mg (Free Sample)	￥280	In stock
10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

XMU-MP-1 is a potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20-like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively.
XMU-MP-1 has a selectivity score of 0.05 against a panel of 468 diverse kinases; inhibits phosphorylation of MOB1 in a dose-dependent manner.
XMU-MP-1 activates the downstream effector Yes-associated protein (YAP) and promotes cell growth.
XMU-MP-1 attenuates acetaminophen-induced liver injury, promotes liver repair and regeneration in mice。
XMU-MP-1 is a valuable chemical probe to study the Hippo signaling pathway

物理化学性质&存储条件

分子量	416.4773
分子式	C17H16N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-

参考文献

1. Fan F, et al. Sci Transl Med. 2016 Aug 17;8(352):352ra108.

2. Liu Z, et al. Adv Mater. 2017 Oct 11. doi: 10.1002/adma.201703393.

XMU-MP-1 (MST1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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XMU-MP-1 (MST1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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