XMD8-87 |CAS:1234480-46-6 Probechem Biochemicals

Chemical Structure : XMD8-87

CAS No.: 1234480-46-6

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XMD8-87 (Ack1 inhibitor B19)

货号: PC-35146Not For Human Use, Lab Use Only.

XMD8-87 (Ack1 inhibitor B19) is a potent Ack1 inhibitor with Kd of 15 nM, inhibits EGF-induced autophosphorylation in HEK293 cells at 2 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

XMD8-87 (Ack1 inhibitor B19) is a potent Ack1 inhibitor with Kd of 15 nM, inhibits EGF-induced autophosphorylation in HEK293 cells at 2 uM.
XMD8-87 completely inhibits A549 cancer cell growth, and partially inhibited EGF-stimulated cancer cell growth at 10 uM.
XMD8-87 is a potent, selective Ack1 (TNK2) inhibitor with IC50 of 1.9 uM in ELISA assays.
XMD8-87 potently block proliferation of TNK2 mutant cell lines, shows IC50s of 38 nM and 113 nM for the D163E and R806Q mutations.

物理化学性质&存储条件

分子量	445.527
分子式	C24H27N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

参考文献

1. Miduturu CV, et al. Chem Biol. 2011 Jul 29;18(7):868-79.

2. Mahajan K, et al. Cancer Lett. 2013 Sep 28;338(2):185-92.

3. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38.

XMD8-87 (Ack1 inhibitor B19)

生物&药学活性

物理化学性质&存储条件

参考文献

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XMD8-87 (Ack1 inhibitor B19)

生物&药学活性

物理化学性质&存储条件

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