XMD8-85 | ERK5 inhibitor | Probechem Biochemicals

Chemical Structure : XMD8-85

CAS No.: 1234479-76-5

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XMD8-85 (ERK5 inhibitor XMD8-85)

货号: PC-72142Not For Human Use, Lab Use Only.

XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
50 mg	￥4980	In stock
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生物&药学活性

XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.
XMD8-85 is selective for ERK5 over tyrosine non-receptor kinase 2 (TNK2, IC50=959 nM), but does inhibit the leucine-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S (IC50 = 26 nM).
XMD8-85 inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50= 0.19 μM).
XMD8-85 also inhibits Brd4/BET family bromodomains, transcriptional regulators required for Nanog expression.

物理化学性质&存储条件

分子量	459.5
分子式	C25H29N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

参考文献

1. Deng, X, et al. Eur. J. Med. Chem. 70, 758-767 (2013).

3. Di Micco R., et al. Cell Rep. 2014;9:234–247.

XMD8-85 (ERK5 inhibitor XMD8-85)

生物&药学活性

物理化学性质&存储条件

参考文献

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XMD8-85 (ERK5 inhibitor XMD8-85)

生物&药学活性

物理化学性质&存储条件

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