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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-XL999
XL999

Chemical Structure : XL999

CAS No.: 705946-27-6

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XL999 (XL-999)

货号: PC-63212Not For Human Use, Lab Use Only.

XL999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2780 In stock
100 mg ￥4580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XL999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively.
XL999 also potently inhibits Axl, Kit and Flt-4.
XL999 does not block c-Met but does block many other targets of XL880 and XL184, reduces the vascularity of RIP-Tag2 tumors.

物理化学性质&存储条件

分子量 445.542
分子式 C26H28FN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one

参考文献

1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.

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