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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-XL784
XL784

Chemical Structure : XL784

CAS No.: 1224964-36-6

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XL784 (XL-784)

货号: PC-26512Not For Human Use, Lab Use Only.

XL784 is a potent limited-spectrum MMP inhibitor with IC50 of 0.81, 120, 10.8, 18, 0.56 nM for MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, also inhibits snake venom metalloproteinase (SVMP) toxin.

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XL784 is a potent limited-spectrum MMP inhibitor with IC50 of 0.81, 120, 10.8, 18, 0.56 nM for MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, also inhibits snake venom metalloproteinase (SVMP) toxin.

物理化学性质&存储条件

分子量 548.92
分子式 C21H22ClF2N3O8S.1/2Mg
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[[4-(4-chlorophenoxy)-3,5-difluorophenyl]sulfonyl]-3-[(hydroxyamino)carbonyl]-, 2-methoxyethyl ester, magnesium salt (2:1)

参考文献

1. Rachel H Clare, et al. Front Pharmacol. 2024 Jan 11:14:1328950.

2. Ennis T, et al. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26.

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