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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Wee1-XL495
XL495

Chemical Structure : XL495

CAS No.: 3040320-94-0

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XL495 (XL-495)

货号: PC-26487Not For Human Use, Lab Use Only.

XL495 is a potent, selective and orally bioavailable PKMYT1 inhibitor, demonstrates dose-dependent antitumor activity, inhibits phosphorylation of CDK1 at Thr14, and induces phosphorylation of KAP1 at Ser824 in CDX tumors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XL495 is a potent, selective and orally bioavailable PKMYT1 inhibitor, demonstrates dose-dependent antitumor activity, inhibits phosphorylation of CDK1 at Thr14, and induces phosphorylation of KAP1 at Ser824 in CDX tumors.

物理化学性质&存储条件

分子量 308.34
分子式 C17H16N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-amino-8-(3-hydroxy-2,6-dimethylphenyl)quinoxaline-6-carboxamide

参考文献

1. Zhu J, et al. J Org Chem. 2026 Apr 6. doi: 10.1021/acs.joc.6c00304.

2. Dana Gwinn, et al. Cancer Res (2025) 85 (8_Supplement_1): 1733.

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