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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Bcr-Abl-XL228
XL228

Chemical Structure : XL228

CAS No.: 898280-07-4

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XL228 (XL-228)

货号: PC-26878Not For Human Use, Lab Use Only.

XL228 (XL-228) is a potent, multi-targeted tyrosine kinase inhibitor with IC50s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src and Lyn, respectively.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XL228 (XL-228) is a potent, multi-targeted tyrosine kinase inhibitor with IC50s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src and Lyn, respectively.

物理化学性质&存储条件

分子量 437.55
分子式 C22H31N9O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

参考文献

1. Noronha G, et al. Curr Top Med Chem. 2008;8(10):905-21.

2. Cortes J, et al. Blood 2008 112:3232

3. Douglas O, et al. Mol Cancer Ther 2009;8(12 Suppl):C192.

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