XL20

Chemical Structure : XL20

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货号: PC-27270Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM.
XL20 does not affect TDP-43 splicing activity.
XL20 demonstrates strong neuroprotection at concentrations as low as 6.25 µM in primary cortical neurons overexpressing TDP-43.
XL20 significantly increases the thermal stability of WT TDP-43 in cell lysates.
XL20 selectively suppresses CR-dependent TDP-43 assembly behaviors including LLPS and aggregation, and confers potent neuroprotection at low micromolar concentrations.
XL20 exhibits good CNS penetration.
XL20 attenuates TDP-43 neurotoxicity in mice and human motor neurons, slows disease progression in mutant TDP-43 transgenic mice.

物理化学性质&存储条件

分子量	352.44
分子式	C19H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexanol, 2-(6-amino-9H-purin-9-yl)-6-[methyl(phenylmethyl)amino]-, (1R,2R,6R)-rel-

参考文献

1. Gao J, et al. Nat Aging. 2026 Jul 3. doi: 10.1038/s43587-026-01166-3.

XL20

生物&药学活性

物理化学性质&存储条件

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XL20

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物理化学性质&存储条件

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