XL188 | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : XL188

CAS No.: 2305045-76-3

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XL188 (XL-188)

货号: PC-60494Not For Human Use, Lab Use Only.

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
XL188 exhibits little to no inhibition against a panel of 41 DUBs.
XL188 promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM.
XL188 is a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.

物理化学性质&存储条件

分子量	574.726
分子式	C32H42N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-3-(4-methylpiperazin-1-yl)propanamide

参考文献

1. Lamberto I, et al. Cell Chem Biol. 2017 Sep 28. pii: S2451-9456(17)30329-X.

XL188 (XL-188)

生物&药学活性

物理化学性质&存储条件

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XL188 (XL-188)

生物&药学活性

物理化学性质&存储条件

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