XL177A | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : XL177A

CAS No.: 2417089-74-6

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XL177A (XL 177A, XL-177A)

货号: PC-38072Not For Human Use, Lab Use Only.

XL177A (XL-177A) is a potent, selective, irreversible USP7 inhibitor with IC50 of 0.34 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
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100 mg		Get quote

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生物&药学活性

XL177A (XL-177A) is a potent, selective, irreversible USP7 inhibitor with IC50 of 0.34 nM.
XL177A inhibits HA-Ub-VS labeling with IC50s of 85 and 8 nM following 30min and 4hr compound preincubations, respectively。
XL177A is a potent USP7 inhibitor (IC50=39 nM) and p53 stabilizer in cyto.
XL177A binds USP7 in the XL188 binding pocket, XL177A binds to and inhibits USP7 with >10-fold selectivity over closely related DUBs.
XL177A activates p53 signaling transcriptome-wide in MCF7 cells. XL177A exerts p53-dependent growth suppression in individual cell lines.

物理化学性质&存储条件

分子量	861.485
分子式	C48H57ClN8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide

参考文献

1. Nathan J Schauer, et al. Sci Rep. 2020 Mar 24;10(1):5324.

XL177A (XL 177A, XL-177A)

生物&药学活性

物理化学性质&存储条件

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XL177A (XL 177A, XL-177A)

生物&药学活性

物理化学性质&存储条件

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