XL-9872-106C |CAS 2894064-53-8 Probechem Biochemicals

Chemical Structure : XL-9872-106C

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XL-9872-106C (XL-106C)

货号: PC-38156Not For Human Use, Lab Use Only.

XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.

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生物&药学活性

XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.
XL-9872-106C (XL-106C) displays selectivity against a panel of 41 purified DUB enzymes.
XL-9872-106C selectively degrade JAK2-V617F and kill JAK2-V617F-expressing Ba/F3 cells.
XL-9872-106C selectively degrades JAK2-V617F in human AML cells, promotes ubiquitin-mediated proteasomal degradation of JAK2-V617F.
Targeting of JOSD1 leads to the death of JAK2-V617F-positive primary acute myeloid leukemia (AML) cells.

物理化学性质&存储条件

分子量	367.427
分子式	C18H17N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-cyano-N-(7-(3,5-dimethylisoxazol-4-yl)benzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide

参考文献

1. Jing Yang, et al. Leukemia. 2022 Jan;36(1):210-220.

XL-9872-106C (XL-106C)

生物&药学活性

物理化学性质&存储条件

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XL-9872-106C (XL-106C)

生物&药学活性

物理化学性质&存储条件

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