XJB-5-131

Chemical Structure : XJB-5-131

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货号: PC-28360Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

XJB-5-131 is hemigramicidin-TEMPO conjugate and mitochondria-targeted ROS and electron scavenger, reduces apoptosis and enhances cell survival in mouse embryonic cells in vitro, improves mitochondrial function.
XJB-5-131 ameliorate intestinal mucosal injury and prolong survival in rats subjected to lethal hemorrhage.
XJB-5-131 significantly suppresses the disease phenotypes and improves mitochondrial function in mouse model of Huntington's disease (HD).
XJB-5-131 suppresses weight loss and improves motor performance.
XJB-5-131 reduces mtDNA damage and maintains mtDNA copy number.
XJB-5-131 improves mitochondrial function in HD150KI animals.
XJB-5-131 protects against 2,3-dimethoxy-1,4-naphthoquinone (DMNQ)-induced loss of mitochondrial spare respiratory capacity (SRC).

物理化学性质&存储条件

分子量	960.25
分子式	C53H81N7O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl ((4S,7S,E)-7-benzyl-8-((S)-2-(((S)-1-(((S)-5-(((benzyloxy)carbonyl)amino)-1-oxo-1-((2,2,6,6-tetramethyl-1-(l1-oxidanyl)piperidin-4-yl)amino)pentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-2-methyl-8-oxooct-5-en-4-yl)carbamate

参考文献

1. Xun Z, et al. Cell Rep. 2012 Nov 29;2(5):1137-42.

2. Macias CA, et al. Ann Surg. 2007 Feb;245(2):305-14.

3. Fink MP, et al. Biochem Pharmacol. 2007 Sep 15;74(6):801-9.

XJB-5-131

生物&药学活性

物理化学性质&存储条件

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XJB-5-131

生物&药学活性

物理化学性质&存储条件

参考文献

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