(E)-Aminoquinol (XIB-4035) | GFRα-1 agonist | Probechem Biochemicals

Chemical Structure : XIB-4035

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XIB-4035 (XIB4035, (E)-Aminoquinol)

货号: PC-70338Not For Human Use, Lab Use Only.

(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).

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生物&药学活性

(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).
(E)-Aminoquinol (XIB-4035) concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM.
(E)-Aminoquinol (XIB-4035) induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.

物理化学性质&存储条件

分子量	456.45
分子式	C26H31Cl2N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-[7-Chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-1,4-pentanediamine

参考文献

1. Hedstrom KL, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30.

2. Tokugawa K, et al. Neurochem Int. 2003 Jan;42(1):81-6.

3. Höke A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1.

XIB-4035 (XIB4035, (E)-Aminoquinol)

生物&药学活性

物理化学性质&存储条件

参考文献

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XIB-4035 (XIB4035, (E)-Aminoquinol)

生物&药学活性

物理化学性质&存储条件

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