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首页-小分子抑制剂&激动剂-Others-Other Targets-XEN445
XEN445

Chemical Structure : XEN445

CAS No.: 1515856-92-4

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XEN445 (XEN 445, XEN-445)

货号: PC-42932Not For Human Use, Lab Use Only.

XEN445 is a potent, selective endothelial lipase (EL) inhibitor with IC50 of 237 nM, displays no significant activity against lipoprotein lipase (LPL) and hepatic lipase (HL) (IC50=20 and 9.5 uM).

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5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XEN445 is a potent, selective endothelial lipase (EL) inhibitor with IC50 of 237 nM, displays no significant activity against lipoprotein lipase (LPL) and hepatic lipase (HL) (IC50=20 and 9.5 uM).
XEN445 demonstrates in vivo efficacy in raising plasma HDLc concentrations in mice, shows good ADME and PK properties.

物理化学性质&存储条件

分子量 366.3344
分子式 C18H17F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 40 mg/mL
Chemical Name/SMILES

Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-

参考文献

1. Sun S, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34.

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