XE991 | Kv7 (KCNQ) inhibitor | Probechem Biochemicals

Chemical Structure : XE991

CAS No.: 122955-42-4

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XE991 (XE-991)

货号: PC-63066Not For Human Use, Lab Use Only.

XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
XE991 displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM.
XE991 enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.

物理化学性质&存储条件

分子量	376.45
分子式	C26H20N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone

参考文献

1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.

3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.

4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.

XE991 (XE-991)

生物&药学活性

物理化学性质&存储条件

参考文献

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XE991 (XE-991)

生物&药学活性

物理化学性质&存储条件

参考文献

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