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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-XDS-23
XDS-23

Chemical Structure : XDS-23

CAS No.:

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XDS-23 (XDS23)

货号: PC-28632Not For Human Use, Lab Use Only.

XDS-23 is a selective biofilm inhibitor with IC50 of 1.26 uM for inhibiting biofilm in P. aeruginosa PAO1, inhibits LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs), suppresses the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides, exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XDS-23 is a selective biofilm inhibitor with IC50 of 1.26 uM for inhibiting biofilm in P. aeruginosa PAO1, inhibits LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs), suppresses the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides, exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo.

物理化学性质&存储条件

分子量 309.75
分子式 C15H16ClNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-butyl-2-((6-chloro-2-oxo-2H-chromen-4-yl)oxy)acetamide

参考文献

1. Liu W, et al. Eur J Med Chem. 2026 Jan 15;302(Pt 1):118294.

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