XCT790 | ERRα inverse agonist | Probechem Biochemicals

Chemical Structure : XCT790

CAS No.: 725247-18-7

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XCT790 (XCT 790;XCT-790)

货号: PC-42580Not For Human Use, Lab Use Only.

XCT790 (XCT-790) is a potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2680	In stock
100 mg		Get quote

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生物&药学活性

XCT790 (XCT-790) is a potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
XCT790 shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM.
XCT790 inhibits PGC-1α regulation of ERRα and ERRα target gene expression.
XCT790 inhibits proliferation in cellular models of breast cancer.

物理化学性质&存储条件

分子量	596.4249
分子式	C23H13F9N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 21 mg/mL
Chemical Name/SMILES	2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-

参考文献

1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.

2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.

3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.

4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.

XCT790 (XCT 790;XCT-790)

生物&药学活性

物理化学性质&存储条件

参考文献

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XCT790 (XCT 790;XCT-790)

生物&药学活性

物理化学性质&存储条件

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